Innovation for

Reproductive Success

Ostara has developed a platform technology that delivers improved success rates in artificial reproduction across a range of mammalian species, from laboratory rodents to domestic livestock. Initial products focus on the murine market.

ProgenySys™ Technology

Ostara’s innovative ProgenySys™ technology will initially focus on the production of
transgenic rodents

ProgenySys™  Ovumouse is a controlled dosing system that stimulates superovulation by delivering timed doses of PMSG, followed 48/50 hours later by a second dose of hCG.

ProgenySys™ PseudoMouse, is a vaginal pessary system for mice, which delivers key factors required to create a permissive environment for embryo implantation in the uteri of prospective recipient females.

ProgenySys™ OvuMouse aids the researcher in producing large numbers of high quality embryos for research or breeding purposes. Current technologies are often inefficient and require many donors in order to produce enough embryos for manipulation. ProgenySys™ OvuMouse refines this process, reducing the number of donors required by increasing the number of embryos yielded per mouse.

ProgenySys™ OvuMouse is delivered vaginally thereby removing the need for invasive intraperitoneal injections. The ProgenySys™ Controlled Dose Delivery System is designed to ease rodent-handling and to overcome the variance in success rates observed with traditional methods that rely on skilled operator technique.

The OvuMouse dosing capsule is sealed to increase product shelf life and colour coded to aid accurate dose timing. The system is activated when the cap is removed, and the dose is delivered by simply depressing the tab. The clear delivery capsule allows the user to clearly see the mouse anatomy and the delivery port is shaped to ensure correct placement prior to dose delivery

ProgenySys™ PseudoMouse, is a vaginal pessary system for mice, which delivers key factors required to create a permissive environment for embryo implantation in the uteri of prospective recipient females. By mimicking the effect of factors found in mouse seminal plasma, ProgenySys™ PseudoMouse induces pseudopregnancy in oestrus females and totally replaces the need for vasectomised (or otherwise sterile) males in transgenic breeding programmes.

Compliance with 3Rs (Replacement, Reduction and Refinement
of animals in research)

Replacement

Methods which avoid or
replace the use of animals

Reduction

Methods which minimise the number of animals used
per experiment

Refinement

Methods which minimise suffering and improve animal welfare

The ProgenySys™ system provides significant advantages for the user:

  • Compliance with 3Rs (Replacement, Reduction and Refinement of animals in research)
    There is an ethical drive from the Home Office (in UK) and equivalent authorities worldwide to reduce numbers of animals in research. All users of animals for experimental purposes have an obligation to demonstrate that their use is justified and that there are no alternatives which require fewer animals. ProgenySys™ aims to make a significant contribution to this goal.
  • Significant cost savings
    Reduction in the number of male and female mice required for breeding programmes will lead to significant cost savings in surgery time, animal housing and overheads.
  • Improved reliability
    Customers can reliably produce the required number of animals for their own studies or for supply to other users, thereby avoiding wastage and unnecessary costs.

Future Products

Ostara's ProgenySysTM suite of products are currently targeted specifically for use in mice, as these are the most widely used model for research into human disease. However, we are currently exploring development of a range of products for use in rats.

 The underlying principles of this technology can also be applied to artificial insemination and embryo transfer technology in the commercial breeding of domestic livestock. The technology could improve implantation rates in high genetic merit cattle, sheep and pigs, where a failure of the uterus to create an embryo-tolerant environment is responsible for failed implantation, early pregnancy loss and small litter sizes which impact on profitability in the agricultural sector.

Home

News

Contact

Ostara Biomedical Limited, Liverpool Science Park,
131 Mount Pleasant, Liverpool, L3 5TF